Drug Screening On Induced Pluripotent Stem Cells As An Effective Form Of Treatment - Free Essay Example

Sample details Pages: 1 Words: 386 Downloads: 6 Date added: 2019/06/26 Category Biology Essay Level High school Tags: Stem Cell Essay Did you like this example? This proving iPSCs are a better option because they have similar findings as the mouse model with more of an advantage linking to the human patients since these iPSCs were from human patients with the disease. Overall the end goal is to find a drug that slows the progression or stops the neurodegeneration in humans for this specific disease and being able to test the drugs out in human cells rather than animal cells would have more advantages. Another important aspect of iPSCs is the number of cells obtained is more than what can be gathered from using a mouse model (1). The number of cells grown is a key factor that leads into using a drug screening and the best part is being able to test small amounts of drugs with large libraries of 3,000 different kinds of compounds (1), which testing many drugs needs an effective way to obtain many cells and can be done with iPSCs. In addition to that, once certain drugs are shown to be effective, also called hits, they can be selected for more in-depth screenings which can also be done on primary cells as well (5). This is very helpful in the fact that the certain drugs can be tested in different types of cells such as Purkinje and dorsal root ganglions since motor neurons are not the only cell type that gets affected by this disease and to test the drugs on them would help give more insight on the drugs affect. Don’t waste time! Our writers will create an original "Drug Screening On Induced Pluripotent Stem Cells As An Effective Form Of Treatment" essay for you Create order Drug screenings are also highly cost-efficient where performing smaller tests on multiple compounds can save more money in the long run (5). Figure 2 is a great depiction of how the flow of drug screening can lead to the end goal (5). The timeline shows how in the beginning, the drug screening is less expensive than the end experiments and once learning more about the hits that were obtained from the first screen then it leads into refinements and optimizing only if the results continues to provide beneficial (5). This is where Gilmore et al.s lab (1) is heading towards with the iPSCs after completions of testing the 384-well plates. In addition, other recent articles such as Chuang et al (2) and Lariosa-Willingham et al (4), discuss the use of drug screening showing this is an acceptable test that is currently still being used in research.

Technological Innovations in the Civil War

Mental Health Care Disparities Among Minority Populations

Mental Health Care Disparities in Minority Populations Erin Bertelson Denver School of Nursing Mental Health Care Disparities in Minority Populations Across the country, a steady increase has been noted in the number of patients presenting to emergency departments for psychiatric complaints (Zun, 2014). Patients also attempt to use their primary care doctors to treat their mental illnesses. The mental health care options for these patients are extremely limited, especially for minority populations such as African Americans and Hispanics. One out of four adults in America suffers from some form of mental illness, yet only one out of three of those affected receives treatment (Safran, 2009). Furthermore, patients are routinely misdiagnosed, receive poor quality of care, receive care from providers who have no understanding of their cultures and values, or are not even able to receive care in the first place (Sanchez, 2012). History The lack of mental health care services for minorities is a long-standing problem in the United States. The first time the issue received attention was in 1985, when the U.S. Department of Health and Huma n Services released a report that described serious health discrepancies that minority populations were enduring. In 1986, because of this report, the Office of Minority Health was formed to assist in the reduction of the health care shortages forShow MoreRelatedThe Impact Of Geography On Mental Health Service Use And Care1552 Words   |  7 Pagesethnic disparities in older black and white adults and the role of geography in mental health service use and care. The critique of this article examined disparities addressed but also the lack of other minorities suffering lack of mental health service use. Reducing racial disparities across the four regions in the South, Northeast, Midwest and West would support improving mental health access at the national level. 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Of most concern are the vulnerable population subgroups known by the harsh environments in which they live, their endangered and unhealthy life styles and the illnesses and injuries that afflict them. â€Å"These subpopulations

The Responsibilities of the Federal Reserve - 1591 Words

Congress has handed over the responsibility for monetary to the Federal Reserve, also known as the Fed, but retains oversight responsibilities in order to ensure that the Federal Reserve adheres to the statutory mandate of stable prices, moderate long-term rates of interest, as well as, maximum employment (Labonte, 2014). The responsibilities of the Fed as the country’s central bank are classified into four: monetary policy, supervision of particular types of banks and financial institutions for soundness and safety, provision of emergency liquidity through the function of the lender of last resort, and the provision of services of the payment system to financial institutions, as well as, the government (Labonte, 2014). The monetary role of the Federal Reserve necessitates aggregate demand management. The Federal Reserve defines monetary policy as the measures it undertakes in order to influence the cost and availability of credit and money to enhance the objectives mandated b y Congress, which is maximum sustainable employment and a stable price level (Appelbaum, 2014). Since the expectations of businesses as capital goods purchasers and households as consumers exert an essential influence on the main section of spending in America, and the expectations are influenced in essential ways by the Federal Reserve’s actions, a wider definition would involve the policies, directives, forecasts of the economy, statements, and other actions by the Federal Reserve, particularly thoseShow MoreRelatedThe Responsibilities and Powers of the Federal Reserve Draft Essay960 Words   |  4 PagesFEDERAL RESERVE DRAFT. 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The Congress was behind the creation of the Federal Reserve with the ultimate goal of making it safer and more reliable to keep the money. The Congress was also compelled to establishingRead MoreThe Federal Reserve System Essay1075 Words   |  5 PagesThe Federal Reserve System The Federal Reserve System was founded by Congress in 1913 to be the central bank of the United States. The Federal Reserve System was founded to be a safer, more flexible, and more stable monetary financial system. Over the years, the role of the Federal Reserve Board and its influence on banking and the economy has increased. Today, the Federal Reserve Systems duties fall into four general categories. Firstly, the FED conducts the nations monetary policy. 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Final goods and services definition is a goods consumed rather than used for further processing. The Real GDP is increased or decreased based Inflation or deflation. Inflation is an increase in the average overall price for goods

Environmental Policy Analysis for Decision Making-Free-Sample

Questions: 1.Explain why the values might be different and which gives rise to the larger Environmental Values. 2.Discount rates can influence the outcome from a benefit Cost analysis. Should a high or low discount rate be used if you are considering a policy that will produce benefits over multiple generation. Answers: 1.There are several methods which are used to study and compare the non-market value of the goods. Out of them the two popular methods are the contingent valuation method, which is popularly known as the CVM method and the other method is the choice modeling. Both of these models are required to check and see the changing environmental aspects around and hence take proper decisions regarding them. Under the CVM method (i.e. the contingent valuation method) the respondents or the consumers are asked for the maximum willingness to pay for the increase and decrease in the quality of the environment around them. The people or the respondents can also be asked or considered having the minimum willingness to accept the compensation for the quality of the environment they live in or dwell in around them. The contingent valuation method is used by a number of people and is used for estimating the value of wide variety of environmental issues and arriving at various estimates. However the contingent method is criticized by a lot of people as it does not help in arriving at the correct estimates about the value of the environmental quality. The next is the choice modeling which is also known as the CM modal and this modal helps in surveying the complex value of the environmental quality. There are various bundles of choice, the values of all differ at various levels and all have different attributes. It is considered as a superior model over the other environmental valuation models(Ritchei Lewis 2013). In this modal rather than maximizing the choices the respondents are made to feel satisfied by the valuation methods. The best choice is seen and it is worked upon so that the consumer or the respondent feels fully satisfied by the choice of the valuation policy. The difference between them is that the CVM method was to estimate and see the maximum willingness to pay by the respondent whereas in the CM method the willingness to accept is seen by the respondents. The respondents are given the choice to accept the program as it is and then pay for the amount which is required or to decline the valuation policy so offered. Hence of the above mentioned grounds the CVM and the CM modals can be differentiated. 2.It is an important thing to know in todays scenario and to decipher that how much of the money one should put in or how much worth it is to put in the world to avoid the disruption of the climate. It is essential to derive at the amount and to value how much the current generation should invest so that the generations to come do not feel the pangs or the problems related to environmental concern. The economists have said that to meet the demand of the future generations and so that they do not feel devoid of any resources one should or the community should discount their todays use. They should use the minimum resources and save them wherever possible. This is known as discounting the resources or discounting or reducing the current consumption so as to meet the future needs. Now, the policies should be made which lead to reducing the current resources and reducing the depletion of the goods in the todays scenario(Loomis Helfand 2006). The generation of today should find alternative uses to the resources which cannot be renewed and hence save the resources for future generations. Discounting the use of resources today, using less of resources which cannot be renewed, and finding alternative methods will help in successful leading a good and happy environment for future generations. The people on the earth use various appliances and things which lead to excess of carbon emissions. The emissions of carbon lead to pollution and hampering the environment which ultimately lead to global warming and increasing the level of pollution. If the policies are formed and implemented which would lead to discounting the current usage of the goods, it will eventually lead to less use of appliances that emit carbon dioxide and hence the emissions and the level of carbon dioxide will decrease in the environment and hence will save the earth from being hampered by the people of the current generations. Hence, if the policies are implemented which will lead to discounting the use of todays resources so as to save the environment for the future generation, it will be a good move to save the environment and hence would have a number of good effects on the earth and human life. Bibliography Loomis, J Helfand, G 2006, Environmental Policy Analysis for Decision Making - Page 157, Wiley Publications, London. Ritchei, J Lewis, J 2013, Qualitative Research Practice: A Guide for Social Science Students, 4th edn, Springer 2013, New York.

Strategic Business Ethics and Social Responsibility

Question: Discuss about the Strategic Business Ethics and Social Responsibility. Answer: Introduction: Yes, Google has implemented a strategy that serves all its stakeholders. Stakeholders are the entities that have an interest in the business operations of the company. The stakeholders of the company include advertisers, government, users, employees, investors and communities. The company provides an opportunity to its users to customize their searches for the purpose of searching information needed by them. Besides this, advertisers can also bid high to provide advertisement on the websites (Dettmer, 2003). This results in increasing the profits of the company and increases its shareholder value. Majority of the sales revenue of the company is generated by the advertisements on different products and services of the company. It also provides an opportunity to companies to display their advertisements as a sponsored links on their products. In addition to this, the company offers a shuttle system to its employees that run on biodiesel (Shankar, et al. 2012). Besides this, it also practiced sharing of the cars on the campus by the employees to roam around. In addition to this, the company has also provided bicycles to the employees to go from one department to other in the campus. In addition to this, it has also developed different tools that are required by non- profit organizations for the purpose of granting money. Users are the top priority stakeholders of the company. The company offers diversified range of products to its users in order to meet their customized needs and wants (Cooper and Edgett, 2009). The company designs its products and services by considering the needs and wants of the users. The company provides high salaries and incentives to its employees in order to retain them with the company. Human resources are considered valuable resource for the company (Aubin and Carlsen, 2008). Google has made efforts to bring changes in its privacy policy and identifies different methods for the purpose of protecting the personal information of the users. There is a heavy reliance on the tracking along with other activities carried out by the Google for the purpose of maintaining its profitability. It has regularly updating its privacy policies in order to comply with the needs and wants of the users related to the private and personal information shared with the company. In addition to this, in the year 2012, the company has combined all the information collected from different products and services provided by it to the users for the purpose of protecting the information provided by the users (Klosek, 2007). This step also helps in maintaining the confidentiality of the information provided by the users. Besides this, Google has provided the option of turning off some of the options that results in collecting the information regarding the users. The new privacy policy does not have any impact on the volume of data rather it facilitates in increasing the commitment of the company towards maintaining the privacy of the information provided by the user (Strandburg and Raicu, 2005). This new privacy policy facilitates in using the information provided by the users by all the products and services offered by the company in order to keep a track on the changing needs and wants of the customers which in turn results in an increase in the profitability of the company. Besides this, the company should provide a option to its users regarding the locking of the password which results in keeping the users information safe and protected. Besides this, the company should take consent of the users for the purpose of sharing of the private and personal information of users with third parties. This results in building trust and loyalty among the users of the Google products and services and results in maintaining the profitability of the company (Zheleva, Terzi and Getoor, 2012). Google is a multinational company that has expanded its operations in various countries around the globe. This is the reason that it has to abide by the rules and regulations as per the different laws and regulations practiced in different countries. There is a significant impact of the rules and regulations of the government on the operations of the Google. There is a presence of strict rules and regulations related to internet in China. There was a presence of great opportunity for Google in China but due to presence of many rules and regulations there is a negative impact on the business operations of Google. The government of China has blocked various sites that are offered by Google due to presence of problems in the search engine of the company (Trepte and Reinecke, 2011). These results in the exit of Google from the Chinese market due to presence of many hackers and shift it to Hong Kong. The other problem faced by Google is problems related to tracking and privacy violations. Google has scanned data related to the users through wireless networks. Besides this, in UK, the company has gathered private information of users through a special detection equipment fitted in vans for the purpose of location based services. The company has to make payment of all fines for the occurrence of the violations made by the company (Custers, et al. 2012). In addition to this, it is tedious task to understand all the rules and regulations of the countries by the company. There is a need of acquiring censorship to enter into a Chinese market and the search engine is blocked by the government in the nation. It also has a slow speed and inconsistent for the users due to which the company has lost its market in the country in a steady pace. Nowadays, companies has made their own industry standards in which the company provide do not track option to the users which results in limiting the information collected related to the personal and private information of the users (Solove, Rotenberg and Schwartz, 2006). References Aubin, D.D.S. and Carlsen, B.J. 2008. Attract, Engage Retain Top Talent: 50 Plus One Strategies Used by the Best. AuthorHouse. Cooper, R.G. and Edgett, S.J. 2009. Product Innovation and Technology Strategy. Stage-Gate International. Custers, B., et al. 2012. Discrimination and Privacy in the Information Society: Data Mining and Profiling in Large Databases. Springer Science Business Media. Dettmer, H.W. 2003. Strategic Navigation: A Systems Approach to Business Strategy. ASQ Quality Press. Klosek, J. 2007. The War on Privacy. Greenwood Publishing Group. Shankar, V., et al. 2012. Handbook of Marketing Strategy. Edward Elgar Publishing. Solove, D.J., Rotenberg, M. and Schwartz, P.M. 2006. Privacy, Information, and Technology. Aspen Publishers Online. Strandburg, K.J. and Raicu, D.S. 2005. Privacy and Technologies of Identity: A Cross-Disciplinary Conversation. Springer Science Business Media. Trepte, S. and Reinecke, L. 2011. Privacy Online: Perspectives on Privacy and Self-Disclosure in the Social Web. Springer Science Business Media. Zheleva, E., Terzi, E. and Getoor, L. 2012. Privacy in Social Networks. Morgan Claypool Publishers.